Madecassic acid is a natural chemical that comes from the plant Centella asiatica. In Korea it is famous for soothing skin, but scientists have now found a new use for it.
Researchers at the University of Kent worked with colleagues at University College London. They used computer models and lab tests to see how madecassic acid affects bacteria.
Why This Matters
Some bacteria, like certain strains of E. coli, no longer respond to old antibiotics. These “superbugs” cause many deaths worldwide. Finding new ways to stop them is a big health priority.
How Madecassic Acid Works
The study, published in RSC Medicinal Chemistry, shows that madecassic acid blocks a protein called cytochrome bd. Bacteria need this protein to breathe and stay alive during infection. Humans do not have cytochrome bd, so the acid can target bacteria without harming our cells.
When the protein is blocked, the bacteria cannot grow. In lab tests, the acid stopped drug‑resistant E. coli from multiplying.
Even Stronger Versions
Scientists also made three slightly changed versions of the acid. All three still stopped the cytochrome bd protein. One of them even killed the bacteria at higher doses.
The researchers plan to keep tweaking these molecules to make them more powerful and safe for future medicines.
What This Could Mean for Skincare
Because madecassic acid is already used in skin creams, the findings raise a question: could the ingredient also help keep the skin’s natural bacteria balanced? More study is needed, but the idea is exciting.