Scientists have created a new type of artificial saliva that comes as a mouthwash. It is made from a sugarcane protein called CANECPI‑5. The product can protect the teeth of people who receive radiation therapy for head and neck cancer.
Why a New Mouthwash Is Needed
Radiation near the mouth often damages the glands that make saliva. Without enough saliva, bacteria grow fast and teeth become weak. This can lead to painful cavities and infections.
How the Sugarcane Protein Works
Researchers found that CANECPI‑5 sticks directly to the surface of the tooth. Once attached, it forms a thin, protective film—similar to the natural “pellicle” that appears on teeth. This film blocks acids from drinks, foods, and even the stomach, keeping enamel strong.
In lab tests, the protein worked best when mixed with fluoride and xylitol. The combination slowed down bacterial activity and reduced the loss of calcium and phosphate that causes cavities.
Benefits for Cancer Patients
There is currently no special product that fights the severe cavities that appear after radiation therapy. The new artificial saliva not only eases the feeling of a dry mouth, but also fights harmful bacteria. Some patients may need it only for a short time, while others might use it permanently because their glands cannot recover.
From Sugarcane Research to Dental Care
The protein started its life in a sugarcane genome project. Scientists first produced a sugarcane cystatin named CANECPI‑1 and later discovered five more, including CANECPI‑5. This version showed strong ability to stick to smooth surfaces, which led to tests on tooth enamel.
Beyond dental use, the protein has shown promise in reducing inflammation and helping wounds heal, suggesting it could be useful in many medical areas.
Future Directions
The research team plans to combine CANECPI‑5 with other ingredients. One idea is to link it with a tiny piece of statherin, a natural saliva protein, to boost protection against stomach acids. Another plan is to pair the protein with vitamin E, which could help carry it onto the tooth surface when patients apply it at home.
Different product forms have already been tested, such as mouthwash, gel, and a dissolving film that sits on the tongue. All versions performed well, and the team will keep exploring new ways to use the protein.
Collaboration and Impact
The study involved scientists from Brazil, the United States, and South Korea. It was part of a larger project aimed at controlling dental mineral loss. The findings were published in a peer‑reviewed dental journal.
CANECPI‑5 is patented, and the next step is to partner with companies that can produce it at a larger scale. If successful, it could become a valuable tool for people dealing with dry mouth and cavity risk after cancer treatment.