Researchers from the University of Oslo, Akershus Hospital and partners wrote a new review for Nature Aging. More than 25 experts looked at a tiny molecule called NAD+ and how it might keep us healthier as we grow older.
NAD+ works like a fuel controller inside each cell. It helps make energy, fixes DNA and keeps cells running well. As we age, NAD+ levels naturally drop. Lower NAD+ is linked to forgetfulness, weaker muscles and a higher chance of diseases such as Alzheimer’s and Parkinson’s.
Scientists are testing ways to raise NAD+ levels. Two popular compounds are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Early clinical trials have shown small improvements in memory, movement and metabolism when people take these supplements.
Even with these hopeful signs, the researchers say we still need bigger and longer studies. Only large trials can tell if the benefits work for many people and for different illnesses.
Interest in NAD+ is growing fast. Trials are happening around the world, including in Norway. At the same time, NR and NMN are already sold as health supplements, which creates debate about which product works best and whether results from animal studies will happen in humans.
To turn early findings into safe medicines, scientists call for more collaboration and stricter testing. Strong teamwork and solid clinical data will be key to turning NAD+ boosters into reliable tools for healthy aging.